Comparison of the Efficacy of Intravenous Ketorolac to that of Intravenous Pethidine in Pain Suppression in Patients with Biliary Colic

Authors: Mohammad Davood Sharifi, Mahdi Foroughian, Fatemeh Maleki, Amir Rahmanian Sharifabad, Roohie Farzaneh, Omid Bameri, Amir Masoud Hashemian

DOI: 10.9734/jpri/2021/v33i331162

Published: 2021

Journal: Journal of Pharmaceutical Research International

Abstract

Aim: The study aimed to compare the effect of intravenous administration of the NSAID (Non-steroidal anti-inflammatory drugs) ketorolac to that of intravenous administration of the opioid pethidine in the suppression of pain in patients with biliary colic.Methodology: The present study is a trial study. Among all the biliary colic patients in Mashhad Referral Hospital Emergency in Iran, 58 patients with inclusion criteria were selected using convenience sampling. They were randomly divided into two groups of 29 patients. In the first group, 1 mg/kg IV pethidine, and in the second group, 30 mg IV ketorolac was injected. The pain severity was assessed prior to the treatment and 15, 30, and 60 minutes after the onset of the treatment using the Visual Analogue Scale (VAS). The data were analyzed using SPSS 20 and Chi-square tests.Findings: The patients' mean age was 45±15 years old (age ranged from 30 to 60 years old). The results showed no significant relationship between pain suppression and medicine type after 15 minutes (P=0.5), 30 minutes (P=0.6), and 1 hour (P=0.7). It means that pethidine and ketorolac have an equal effect on pain suppression in patients with biliary colic. Also, the more time passes from the injection, the more the medicines suppress pain.Conclusion: the results of this study show that the efficacy of NSAIDs in the suppression of moderate to severe pain; therefore, a plan to use NSAIDs instead of narcotics for this purpose is essential.

Keywords: Biliary colic, pethidine, ketorolac, pain

Amir Masoud Hashemian, Omid Bameri, Roohie Farzaneh, Amir Rahmanian Sharifabad, Fatemeh Maleki, Mahdi Foroughian & Mohammad Davood Sharifi. (2021). Comparison of the Efficacy of Intravenous Ketorolac to that of Intravenous Pethidine in Pain Suppression in Patients with Biliary Colic. Journal of Pharmaceutical Research International, 33(3), 67–73. https://doi.org/10.9734/jpri/2021/v33i331162

Amir Masoud Hashemian, Omid Bameri, Roohie Farzaneh, Amir Rahmanian Sharifabad, Fatemeh Maleki, Mahdi Foroughian and Mohammad Davood Sharifi. Comparison of the Efficacy of Intravenous Ketorolac to that of Intravenous Pethidine in Pain Suppression in Patients with Biliary Colic. J. Pharm. Res. Int. [Internet]. 2021 Feb. 20 [cited 2025 Nov. 6];33(3):67–73. Available from: https://journaljpri.com/index.php/JPRI/article/view/2016

@article{hashemian_comparison_2021, title = {Comparison of the {Efficacy} of {Intravenous} {Ketorolac} to that of {Intravenous} {Pethidine} in {Pain} {Suppression} in {Patients} with {Biliary} {Colic}}, copyright = {All rights reserved}, issn = {2456-9119}, url = {https://journaljpri.com/index.php/JPRI/article/view/2016}, doi = {10.9734/jpri/2021/v33i331162}, abstract = {Aim: The study aimed to compare the effect of intravenous administration of the NSAID (Non-steroidal anti-inflammatory drugs) ketorolac to that of intravenous administration of the opioid pethidine in the suppression of pain in patients with biliary colic. Methodology: The present study is a trial study. Among all the biliary colic patients in Mashhad Referral Hospital Emergency in Iran, 58 patients with inclusion criteria were selected using convenience sampling. They were randomly divided into two groups of 29 patients. In the first group, 1 mg/kg IV pethidine, and in the second group, 30 mg IV ketorolac was injected. The pain severity was assessed prior to the treatment and 15, 30, and 60 minutes after the onset of the treatment using the Visual Analogue Scale (VAS). The data were analyzed using SPSS 20 and Chi-square tests. Findings: The patients’ mean age was 45±15 years old (age ranged from 30 to 60 years old). The results showed no significant relationship between pain suppression and medicine type after 15 minutes (P=0.5), 30 minutes (P=0.6), and 1 hour (P=0.7). It means that pethidine and ketorolac have an equal effect on pain suppression in patients with biliary colic. Also, the more time passes from the injection, the more the medicines suppress pain. Conclusion: the results of this study show that the efficacy of NSAIDs in the suppression of moderate to severe pain; therefore, a plan to use NSAIDs instead of narcotics for this purpose is essential.}, urldate = {2023-11-30}, journal = {Journal of Pharmaceutical Research International}, author = {Hashemian, Amir Masoud and Bameri, Omid and Farzaneh, Roohie and Sharifabad, Amir Rahmanian and Maleki, Fatemeh and Foroughian, Mahdi and Sharifi, Mohammad Davood}, month = feb, year = {2021}, pages = {67–73}, }